unstuff, loosen up: cause to become unblocked "The medicine unstuffed my nose in minutes!"
relax, loosen up: become less tense, less formal, or less restrained, and assume a friendlier manner "our new colleague relaxed when he saw that we were a friendly group"
limber up, warm up, loosen up: make one's body limber or suppler by stretching, as if to prepare for strenuous physical activity
relax, loosen up, unbend, unwind, decompress, slow down: become less tense, rest, or take one's ease "He relaxed in the hot tub", "Let's all relax after a hard day's work"